P16INK4A DERIVED PEPTIDES FOR PROPHYLAXIS AND THERAPY OF HPV-ASSOCIATED TUMORS AND OTHER P16INK4A EXPRESSING TUMORS

摘要

Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-γ secretion of T cells or inducing proliferation of T cells and the use of said fragments for immunizing an individual against HPV-associated or other p16INK4a expressing carcinomas, preferably advanced carcinomas.

主权项

1. A fragment of the cyclin-dependent kinase inhibitor p16INK4 capable of inducing an immune response against p16INK4a, consisting of
(a) any one of the following amino acid sequences:(SEQ ID NO: 1)(a1) MEPAAGSSMEPSADWLATAAARGRV; (SEQ ID NO: 2)(a2) TAAARGRVEEVRALLEAGALPNAPNSY; (SEQ ID NO: 3)(a3) LPNAPNSYGRRPIQVMMMGSARVAELL; (SEQ ID NO: 4)(a4) VMMMGSARVAELLLLHGAEPNCADPATLTR; (SEQ ID NO: 5)(a5) ADPATLTRPVHDAAREGFLDTLVVLHRAGARL; (SEQ ID NO: 6)(a6) HRAGARLDVRDAWGRLPVDLAEELGHRDVAR; (SEQ ID NO: 7)(a7) GHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD; or
(b) a combination of fragments of (a).