NOVEL DISUBSTITUTED ADAMANTYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR INHIBITING THE METASTASIS OF CANCER CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a novel disubstituted adamantyl derivative or a pharmaceutically acceptable salt thereof, a method for producing same, and an anticancer pharmaceutical composition for inhibiting the metastasis of cancer. The disubstituted adamantyl derivative of the present invention inhibits an HIF-1 enzyme related to the metastasis of cancer so that the production of a protein of a twist which is a protein related to the metastasis of cancer is concentration-dependently inhibited. Accordingly, the metastasis of cancer cells is excellently inhibited by inhibiting the activation of β-catenin and Rho protein (RohA) which are proteins related to the metastasis of cancer and of MMP2 and MMP9 which are genes related to EMT. Also, the disubstituted adamantyl derivative is not cellulotoxic so as not to have an accompanying side effect caused by cellulotoxicity even when absorbed in the human body. The disubstituted adamantyl derivative can be usefully applied as an anticancer pharmaceutical composition for inhibiting the metastasis of cancer.