| 发明名称 |
NANOPARTICLES FOR DELIVERY OF LIGANDS |
| 摘要 |
Disclosed is a nanoparticulate complex comprising an artificial phosphate receptor of formula (I): P-[L-[-N(CH2-2-pyridyl)2]]p.pZN2+ (I) wherein P represents a nanoparticulate substrate, L represents a linking group, and p is an integer of ≧1. Also disclosed are a method for silencing a gene in a cancer patient in need thereof, a method for treating or preventing cancer in a patient in need thereof, and a method for targeting a cell in cancer treatment comprising use of the nanoparticulate complex, for example, a DPA/Zn-functionalized nanoparticulate complex. |
| 申请公布号 |
US2014162966(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201314086111 |
申请日期 |
2013.11.21 |
| 申请人 |
The U.S.A, as represented by the Secretary, Department of Health & Human Services |
发明人 |
Chen Xiaoyuan;Lee Seulki;Choi Ki Young;Liu Gang |
| 分类号 |
C07J41/00 |
主分类号 |
C07J41/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A nanoparticulate complex comprising an artificial phosphate receptor of formula (I):
P-[L-[-N(CH2-2-pyridyl)2]]p.pZn2+ (I) wherein P represents a nanoparticulate substrate, L represents a linking group, and p is an integer of ≧1, in combination with an anion or anions.
|
| 地址 |
Bethesda MD US |
