| 发明名称 |
MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS |
| 摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
| 申请公布号 |
HK1098071(A1) |
申请公布日期 |
2014.06.06 |
| 申请号 |
HK20070105547 |
申请日期 |
2007.05.28 |
| 申请人 |
SEATTLE GENETICS INC. |
发明人 |
SVETLANA O. DORONINA;PETER D. SENTER;BRIAN E. TOKI;ALLEN J. EBENS;TONI BETH KLINE;PAUL POLAKIS;MARK X. SLIWKOWSKI;SUSAN D. SPENCER |
| 分类号 |
C07K;A61K;A61K38/00;A61K38/06;A61K39/395;A61K47/48;C07K16/46 |
主分类号 |
C07K |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
