ASSAY OF CELL MEDIATED IMMUNE RESPONSIVENESS

摘要

This disclosure relates generally to the field of immunological-based diagnostic assays including an assay to measure cell-mediated immunoresponsiveness. The present disclosure teaches determination of the state, progression and/or severity of disease conditions based on a subject's cell-mediated immunoresponsiveness. The assay contemplated herein is capable of integration into standard pathology architecture to provide a diagnostic reporting system and to facilitate point of care clinical management.

主权项

1. A method for measuring cell-mediated immune response activity in a subject, said method comprising contacting lymphocytes from the subject with an antigen and a limiting amount of a Toll-like receptor (TLR) agonist and measuring the presence or elevation in the level of an immune effector molecule from immune cells wherein the presence or level of the immune effector molecule is indicative of the level of cell-mediated responsiveness of the subject.