| 发明名称 |
CONJUGATED ANTI-CD38 ANTIBODIES |
| 摘要 |
Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. |
| 申请公布号 |
US2014155584(A1) |
申请公布日期 |
2014.06.05 |
| 申请号 |
US201113977207 |
申请日期 |
2011.12.30 |
| 申请人 |
Elias Kathleen Ann;Landes Gregory;Singh Shweta;Korver Wouter;Drake Andrew Walling;Haak-Frendscho Mary;Snell Gyorgy Pal;Bhaskar Vinay |
发明人 |
Elias Kathleen Ann;Landes Gregory;Singh Shweta;Korver Wouter;Drake Andrew Walling;Haak-Frendscho Mary;Snell Gyorgy Pal;Bhaskar Vinay |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising:
a) a heavy chain variable region comprising:
i) a first CDR comprising SEQ ID NO:3;ii) a second CDR comprising SEQ ID NO:4;iii) a third CDR comprising SEQ ID NO:5; and b) a light chain variable region comprising:
i) a first CDR comprising SEQ ID NO:6;ii) a second CDR comprising SEQ ID NO:7;iii) a third CDR comprising SEQ ID NO:8; and c) a covalently attached drug moiety.
|
| 地址 |
San Francisco CA US |
