Petroleum jelly-free unguent compositions comprising vitamin D compounds and optionally steroidal anti-inflammatory agents

摘要

Novel compositions in petroleum jelly-free unguent form, in particular for topical application, contain a vitamin D compound and optionally an active agent of the family of steroidal anti-inflammatory agents.

主权项

1. An anhydrous unguent composition, comprising by weight relative to the total weight thereof:
a) 0.00001 to 5% of at least one vitamin D compound, selected from the group consisting of calcipotriol, calcitriol, doxercalciferol, secalcitol, maxacalcitol, seocalcitol, tacalcitol, paricalcitol, falecalcitriol, 1α,24S-dihydroxyvitamin D2, 1(S),3(R)-dihydroxy-20(R)-[((3-(2-hydroxy-2-propyl)phenyl)methoxy)methyl]-9,10-secopregna-5(Z),7(E),10(19)triene, and {4-[6-ethyl-4′-(1-ethyl-1-hydroxypropyl)-2′-propylbiphenyl-3-yloxymethyl]-2-hydroxymethylphenyl}methanol, b) 10 to 40% of glyceryl behenate, c) 1 to 50% of alcohol, glycol, and/or oil having a boiling point greater than 40° C., and d) 0.5 to 10% of an additional lipophilic thickening agent or gelling agent, wherein the composition contains no petroleum jelly or polyorganosiloxane elastomer.