发明名称 |
METHODS FOR TREATING BIOPROSTHETIC TISSUE USING A NUCLEOPHILE/ELECTROPHILE IN A CATALYTIC SYSTEM |
摘要 |
Methods for treating a bioprosthetic tissue are described herein. The methods comprise contacting the bioprosthetic tissue with at least one nucleophile and/or at least one electrophile in the presence of a catalytic system comprising at least one or a combination of a fluoride-based salt, a cesium-based salt, a potassium-based salt, a rubidium-based salt, or a carbonate-based salt. The methods may be used to alter functional groups on biological tissue which represent actual and potential calcium binding sites and also processes for cross-linking bioprosthetic tissue. Both processes may be used in conjunction with known fixative techniques, such as glutaraldehyde fixation, or may be used to replace known fixative techniques. |
申请公布号 |
CA2885935(A1) |
申请公布日期 |
2014.05.15 |
申请号 |
CA20132885935 |
申请日期 |
2013.11.08 |
申请人 |
EDWARDS LIFESCIENCES CORPORATION |
发明人 |
XU, DENGFENG;DOVE, JEFFREY S. |
分类号 |
A61L27/56;A61L27/38;C12N5/07 |
主分类号 |
A61L27/56 |
代理机构 |
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代理人 |
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