摘要 |
An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group—CH═, R1 represents a group—Z—R6, in which Z represents a group—CO—, a group—CH(OH)—or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group—O—, a group—CO—, a group—CH(OH)—or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like. |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUYAMA, HIRONORI;OHNISHI, KENJI;NAKAGAWA, TAKASHI;TAKASU, HIDEKI;SAKAMOTO, MAKOTO;HIGUCHI, KUMI;MIYAJIMA, KEISUKE;YAMADA, SATOSHI;MOTOYAMA, MASAAKI;KOJIMA, YUTAKA;YASUMURA, KOICHI;KODAMA, TAKESHI;OTSUJI, SHUN;KAN, KEIZO;SUMIDA, TAKUMI |