| 摘要 |
<p>Disclosed are methods, kits or arrays for detecting, preventing or treating a condition in a subject. The methods comprise a polymorphic sequence as a biomarker in a sample from the subject, thereby determining that the subject is suffering from, at risk for, or suspected of suffering from diabetic kidney complications, a diabetic kidney disease, or cardiovascular disease. Disclosed also are methods or use of the polymorphic sequence for treating diabetic kidney complications, a diabetic kidney disease, or cardiovascular disease. In particular, the polymorphisms are selected from the group consisting of rs10493064 in DLGAP3 gene, rs10199869 in CRIM1 gene, and rs16865645 in PDE11A gene, rsl459865 in NELL1 gene, rs559519 in MPPED2 gene, rs7953138 in MON2 gene, rs1241486 in STXBP6 gene and rs1241499 in STXBP6 gene.</p> |
