| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new compounds of structural formula I that possess inhibitory activity on phosphatidyl inositol-3-kinase (PI3-kinase). In formulaI: B represents group of formulaII:, wherein Wrepresents 6-10-merous aryl, q is equal to 0, 1, 2, 3 or 4; X is absent or represents -(CH(R))-, z is equal to 1; Y represents -N(R)-; WrepresentsRand Rrepresents Calkyl or halogeno; Rrepresents hydrogen or Calkyl; and in each case Rindependently represents hydrogen or Calkyl.EFFECT: invention refers to a pharmaceutical composition containing the above compounds, and to a method for P3I-kinase inhibition in a subject, wherein the subject suffers a disease representing cancer, a bone disorder, an inflammatory disease, an immune disease, a nervous system disease, a metabolic disease, a respiratory disease, thrombosis or a cardiovascular disease.24 cl, 11 dwg, 6 tbl, 43 ex |
