摘要 |
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis. |
申请人 |
NITTO DENKO CORPORATION |
发明人 |
AKOPIAN, VIOLETTA;MINOMI, KENJIRO;NIITSU, YOSHIRO;PAYNE, JOSEPH E.;KNOPOV, VICTOR;WITTE, RICHARD P.;AHMADIAN, MOHAMMAD;PERELMAN, LOREN A.;TANAKA, YASUNOBU;FEINSTEIN, ELENA;AVKIN-NAHUM, SHARON;KALINSKI, HAGAR;METT, IGOR;YING, WENBIN;LIU, YUN |