发明名称 |
GENETICALLY ENGINEERED STRAIN WSJ-IA FOR PRODUCING ISOVALERYL SPIRAMYCIN I. |
摘要 |
A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, comprising the steps of: (a) constructing a recombinant plasmid comprising a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I - producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively comprising a single gene ist. |
申请公布号 |
EP2597152(A4) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20110809152 |
申请日期 |
2011.07.21 |
申请人 |
SHENYANG TONGLIAN GROUP CO., LTD. |
发明人 |
WANG, YIGUANG;JIANG, YANG;YANG, SHENGWU;ZHAO, XIAOFENG |
分类号 |
C12N1/21;C12N15/63;C12N15/76;C12P19/62;C12R1/465 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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