发明名称 |
N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS |
摘要 |
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives. |
申请公布号 |
KR20140041941(A) |
申请公布日期 |
2014.04.04 |
申请号 |
KR20147006611 |
申请日期 |
2007.03.16 |
申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;CARDIOXYL PHARMACEUTICALS, INC. |
发明人 |
TOSCANO JOHN P.;BROOKFIELD FREDERICK ARTHUR;COHEN ANDREW D.;COURTNEY STEPHEN MARTIN;FROST LISA MARIE;KALISH VINCENT JACOB |
分类号 |
C07C311/16;C07D309/10 |
主分类号 |
C07C311/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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