Mixed crystal agomelatine (form-VIII), preparation method, use thereof and pharmaceutical composition containing the same

摘要

The invention provides a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof, and a pharmaceutical composition containing the same.The said mixed crystal mainly contains an agomelatine crystal form VI. The mixed crystal form is stable and has good reproducibility. It is found through a stability test to be superior to a crystal form VI in terms of stability. Therefore, the crystal form-VIII of the present invention has an advantage in terms of preparation.