发明名称 |
DNA EXHIBITING NERVE ACTIVITY-DEPENDENT PROMOTER ACTIVITY, AND VECTOR CONTAINING SAID DNA |
摘要 |
<p>The present invention addresses the problem of providing an artificial promoter which exhibits nerve activity-dependent activity and high sensitivity and has a great dynamic range, and of providing a method for identifying a nerve activity site by using said promoter. The present invention provides a DNA exhibiting nerve activity-dependent promoter activity, wherein a fragment containing the CREB binding site, the MEF2 binding site and the SRF binding site from among the synaptic activity-responsive elements (SAREs) on the promoter of an Arc/Arg3.1 gene contains a construct that is connected in tandem at least twice.</p> |
申请公布号 |
WO2014045674(A1) |
申请公布日期 |
2014.03.27 |
申请号 |
WO2013JP68289 |
申请日期 |
2013.07.03 |
申请人 |
THE UNIVERSITY OF TOKYO |
发明人 |
BITO, HARUHIKO;OKUNO, HIROYUKI;KAWASHIMA, TAKASHI |
分类号 |
C12N15/09;A01K67/027;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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