发明名称 |
Tissue protective peptides and uses thereof |
摘要 |
Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides. |
申请公布号 |
US8673861(B2) |
申请公布日期 |
2014.03.18 |
申请号 |
US201213448345 |
申请日期 |
2012.04.16 |
申请人 |
CERAMI ANTHONY;BRINES MICHAEL;COLEMAN THOMAS;ARAIM PHARMACEUTICALS, INC. |
发明人 |
CERAMI ANTHONY;BRINES MICHAEL;COLEMAN THOMAS |
分类号 |
A61K38/10;A61K35/34;A61K35/37;A61K35/42;A61P11/00 |
主分类号 |
A61K38/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|