QUINOLINE DERIVATIVE HAVING TLR INHIBITORY ACTIVITY

摘要

A compound represented by general formula (1), a salt of the compound, or a solvate of the compound or the salt, which can inhibit TLR3, 7 and/or 9 and has an excellent prophylactic and/or therapeutic effect on autoimmune diseases, inflammations, allergies, asthma, graft rejection, GvHD or cardiomyopathy associated with sepsis. A: a (substituted) 5- to 6-membered saturated nitrogen-containing heterocyclic ring; Y: a bond or a phenylene group; Z: a bond, a C1-6 alkylene group, N-R7 or O; R1, R3 and R5 to R8: H, a C1-3 alkyl group or the like; R7: H, a C1-6 alkyl group or a 2-nitrobenzenesulfonyl group; and R2 and R4: one represents R8 and the other represents a group represented by formula (2) (wherein B: a (substituted) carbocyclic/heterocyclic ring, W: a C2-6 alkenylene group or the like, X, V: a bond, C(O)NH, NHC(O) or the like, and U: a bond or a C1-6 alkylene group; wherein a case in which each of X, V and U is a bond is excluded).