| 发明名称 |
METHOD FOR PRODUCING HUMAN CERAMIDE USING TRANSFORMED YEAST |
| 摘要 |
<p>The present invention provides a method for producing human ceramide in a yeast cell. The method of the present invention comprises:
1) introducing the sphingoid ”4-desaturase gene (DES1) by transformation of the yeast cell;
2) abolishing the expression of the yeast sphinganine C4-hydroxylase gene (SUR2) by transformation of the yeast cell; and
3) abolishing the expression of the yeast sphingoid base kinase gene (LCB4) by transformation of the yeast cell.</p> |
| 申请公布号 |
EP2157186(B1) |
申请公布日期 |
2014.02.19 |
| 申请号 |
EP20080764400 |
申请日期 |
2008.05.20 |
| 申请人 |
SUNTORY HOLDINGS LIMITED;HIROSHIMA UNIVERSITY |
发明人 |
KODAMA, YUKIKO;OKUHARA, HIROAKI;FUNATO, KOICHI |
| 分类号 |
C12P13/00;C12N1/19;C12N15/12;C12N15/53 |
主分类号 |
C12P13/00 |
| 代理机构 |
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