| 发明名称 |
NOVEL PROCESS AND INTERMEDIATES |
| 摘要 |
<p>The present invention relates to a process for the preparation of steroidal 17.beta.-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17.beta.-carboxylic thioates, such as fluticasone propionate formula (I), using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds formula (II) resulting in selective and controlled fluorination. The present invention also relates to intermediates formula (II) and their preparation.</p> |
| 申请公布号 |
CA2654644(C) |
申请公布日期 |
2014.02.18 |
| 申请号 |
CA20072654644 |
申请日期 |
2007.06.11 |
| 申请人 |
GENERICS [UK] LIMITED |
发明人 |
GORE, VINAYAK G.;GADAKAR, MAHESHKUMAR;POKHARKAR, K.;WAKCHAURE, V. |
| 分类号 |
C07J31/00;A61K31/56;A61P5/44 |
主分类号 |
C07J31/00 |
| 代理机构 |
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| 主权项 |
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| 地址 |
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