| 摘要 |
<p>[Problem] To provide an exceptional agent for preventing or treating dementia and schizophrenia, the agent being based on a serotonin 5-HT5A receptor regulating action. [Solution] The inventors perfected the invention upon discovering that a tetrahydroisoquinoline derivative characterized by having a structure in which an acylguanidino group is bonded to an N atom of a tetrahydroisoquinoline ring, and a ring group is bonded to an unsaturated ring, has a powerful 5-HT5A receptor regulating action as well as an exceptional pharmacological action based thereon; and learning that the tetrahydroisoquinoline derivative is useful as an agent for preventing or treating dementia, schizophrenia, and other conditions.</p> |
