摘要 |
Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is -H or -CH3; and Y is Formula (II) or Formula (III), wherein R2 is -H, -CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers. |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
AMIDON, BENJAMIN, S.;CARDIN, DAVID, P.;GOULD, ALEXANDRA, E.;GREENSPAN, PAUL, D.;HARRISON, SEAN, J. |