| 摘要 |
PROBLEM TO BE SOLVED: To provide novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders.SOLUTION: The present invention relates to an immunogen comprising an antigenic IgE peptide preferably linked to an immunogenic carrier. Said antigenic IgE peptide might be modified for conjugation purposes, preferably by the addition of cysteine or lysine residues and/or the addition of linkers such as GC/GGC linkers. In preferred embodiments, said antigenic IgE peptide is conformationally constrained, preferably simply constrained. Said immunogenic carrier is a heterologous protein, preferably a virus-like particle (VLP), more preferably a HBcAg, HBsAg or Qbeta VLP. The invention also relates to methods for producing such antigenic IgE peptide preferably linked to an immunogenic carrier. |
