| 发明名称 |
USE OF CART19 TO DEPLETE NORMAL B CELLS TO INDUCE TOLERANCE |
| 摘要 |
<p>The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.</p> |
| 申请公布号 |
CA2876734(A1) |
申请公布日期 |
2014.01.16 |
| 申请号 |
CA20132876734 |
申请日期 |
2013.07.12 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
LEVINE, BRUCE L.;KALOS, MICHAEL D.;JUNE, CARL H. |
| 分类号 |
A61K48/00;A61K38/17 |
主分类号 |
A61K48/00 |
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