摘要 |
This invention relates generally to antibody-drug conjugates (ADCs). In particular, the invention relates to ADCs which comprise an antibody or antigen-binding fragment thereof which binds to prostate-specific membrane antigen (PSMA) and is conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine. The antibody-drug conjugate has a PC-3(TM) cell to C4-2 or LNCaP(TM) cell selectivity of at least 250. The invention also relates, in part, to compositions of and methods of using the ADCs. The methods provided include, for example, methods for treating a PSMA-mediated disease. |
申请人 |
PSMA DEVELOPMENT COMPANY, L.L.C. |
发明人 |
DORONINA, SVETLANA, O.;TOKI, BRIAN, E.;SENTER, PETER, D.;MA, DANGSHE;MADDON, PAUL, J.;OLSON, WILLIAM, C. |