PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENTS OF PARKINSON'S DISEASE CONTAINING THE EXTRACT OF LYSIMACHIA CLETHROIDES

摘要

A pharmaceutical composition of the present invention containing an extract of Lysimachia clethroides significantly protected dopaminergic neurons in the Parkinson's animal model, increased dopamine levels, and significantly inhibited microglial activation and neuroinflammation. Thus, the pharmaceutical composition significantly reduced ataxia, which is a symptom of Parkinson's disease. Further, the extract of Lysimachia clethroides significantly inhibited the increase in IL-6 expression in the Parkinson's animal model, which was proved to be a main action mechanism. Therefore, the pharmaceutical composition of the present invention can exhibit effects of treatment and prevention of Parkinson's disease by the extract of Lysimachia clethroides contained therein. [Reference numerals] (AA) Pharmacological effect of the extract of Lysimachia clethroides on the reduction of tyrosine hydroxylase expression (evaluated by immunohistochemical staining) in (A) Striatum and (B) Substantia nigra induced by MPTP in wild-type or IL-6 knockout [IL-6 (-/-)] mice. Veh=Vehicle. Each value means the mean 짹 SEM. ^*P <0.05, ^**P < 0.01 vs, corresponding Vehicle + Saline, ^*P <0.05,^**P < 0.01 vs Wild-type/ Vehicle + MPTP, ^&P < 0.05 vs IL-6 (-/-)/ Vehicle + MPTP (one-way ANOVA. followed by Fisher's PLSD post hoc test)