发明名称 |
pH-SENSITIVE COMPOSITIONS FOR DELIVERY OF BETA LAPACHONE AND METHODS OF USE |
摘要 |
Disclosed herein are compounds comprising a polymer conjugated with a pH-sensitive prodrug of beta-lapachone, wherein the compound is capable of forming a micelle, and wherein the pH-sensitive prodrug comprises a pH-sensitive linker selected from the group consisting of: an aryl imine and an aliphatic imine. Also provided are micelles comprised of such polymer-prodrug conjugates. Further provided are methods for treating cancer with the micelles. |
申请公布号 |
US2013331426(A1) |
申请公布日期 |
2013.12.12 |
申请号 |
US201113825524 |
申请日期 |
2011.08.11 |
申请人 |
GAO JINMING;BOOTHMAN DAVID;ZHOU YINJIAN;BEY ERIK;THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GAO JINMING;BOOTHMAN DAVID;ZHOU YINJIAN;BEY ERIK |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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