NOVEL PROTEIN AND USE THEREOF

摘要

The present invention relates to a novel protein, a biosensor including the same, a method for manufacturing the biosensor, an immunoassay method using the biosensor, a column for isolating and purifying a specific antigen in which an antibody is conjugated to silica-containing solid phase on which the protein is conjugated, a method for isolation and purification using the column, and an in vivo drug carrier. The present invention provides a technique attaching the antibody to biocompatible silica using the protein comprising: N-terminal having a high affinity with the silica; and C-terminal having an affinity with the Fc region of the antibody. In case of using the protein as a linker, the attached antibody gets suitable orientation, thereby having a high antigen detection sensitivity as the biosensor. Also, since antibodies against various kinds of antigens can be conjugated to the silica-containing solid phase through the protein, the protein can be used for the biosensor for various kinds of antigens having specific antibodies, the immunoassay, isolation and purification, target specific drug delivery, and target specific imaging, thereby being used in various fields.