发明名称 OXYPYRIMIDINES AS SYK MODULATORS
摘要 The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
申请公布号 US2013317029(A1) 申请公布日期 2013.11.28
申请号 US201113882958 申请日期 2011.11.01
申请人 PANDEY ANJALI;XU QING;HUANG WOLIN;JIA ZHAOZHONG J.;SONG YONGHONG;PORTOLA PHARMACEUTICALS, INC. 发明人 PANDEY ANJALI;XU QING;HUANG WOLIN;JIA ZHAOZHONG J.;SONG YONGHONG
分类号 C07D239/48;C07D401/12;C07D403/12;C07D405/12;C07D417/12 主分类号 C07D239/48
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