发明名称 |
METHODS FOR ENGINEERING ALLOGENEIC AND IMMUNOSUPPRESSIVE RESISTANT T CELL FOR IMMUNOTHERAPY |
摘要 |
Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppressive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.
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申请公布号 |
US2013315884(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
US201313892805 |
申请日期 |
2013.05.13 |
申请人 |
GALETTO ROMAN;GOUBLE AGNES;GROSSE STEPHANIE;MANNIOUI CECILE;POIROT LAURENT;SCHARENBERG ANDREW;SMITH JULIANNE |
发明人 |
GALETTO ROMAN;GOUBLE AGNES;GROSSE STEPHANIE;MANNIOUI CECILE;POIROT LAURENT;SCHARENBERG ANDREW;SMITH JULIANNE |
分类号 |
A61K35/14 |
主分类号 |
A61K35/14 |
代理机构 |
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地址 |
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