发明名称 |
METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE |
摘要 |
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof |
申请公布号 |
KR20130128308(A) |
申请公布日期 |
2013.11.26 |
申请号 |
KR20127032164 |
申请日期 |
2011.05.06 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;THE UNIVERSITY OF KANSAS;CLEAVE BIOSCIENCES, INC. (CLEAVE) |
发明人 |
DESHAIES RAYMOND J.;CHOU TSUI FEN;SCHOENEN FRANK J.;LI KELIN;FRANKOWSKI KEVIN J.;AUBE JEFFREY;GERRITZ SAMUEL W.;ZHOU HAN JIE |
分类号 |
A61K31/517;A61K31/4184;A61K31/53;A61P35/00 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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