| 摘要 |
<p>The instant invention provides methods of treating breast cancer in a subject suffering there from comprising administering a therapeutically effective amount of an mTor inhibitor, an anti-IGF-IR antibody and an aromatase inhibitor. In one embodiment of the methods of the invention, the mTOR inhibitor is rapamycin, a rapamycin analog selected from ridaforolimus, everolimus, or temsirolimus, or a combination thereof. In another embodiment of the methods of the invention, the anti-IGF-1 R antibody is selected from dalotuzumab, robatumumab, figitumumab, cixutumumab, ganitumab, Roche RI507 and EM164. In a further embodiment, the aromatase inhibitor is selected from letrozole, exemestane, fulvestrant or anastrozole.</p> |
