发明名称 |
Process to control particle size |
摘要 |
A multi-stage process to control the particle size of a pharmaceutical substance comprising the steps of: passing the pharmaceutical substance through a first stage of a particle size reduction process with a first set of particle size control parameters to obtain a feedstock of reduced median particle size and lesser distribution of median particle size for a second stage of a particle size reduction process; passing the feedstock, through a second stage of a particle size reduction process with a second set of particle size control parameters; optionally, using the product of the second stage or subsequent stages as a feedstock in further stages of a multi-stage particle size reduction process with a set of particle size control parameters for each stage; and collecting a pharmaceutical substance with a median particle size greater than 10µm and with a narrow, reproducible distribution of median particle sizes. |
申请公布号 |
AU2006313009(B2) |
申请公布日期 |
2013.10.24 |
申请号 |
AU20060313009 |
申请日期 |
2006.11.10 |
申请人 |
ALPHAPHARM PTY LTD |
发明人 |
MOONEY, BRETT ANTONY;KERAMIDAS, PANAGIOTIS (PETER) |
分类号 |
A61K9/00;A61J3/02;A61K9/14;A61K9/20 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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