POLY(ACRYLATE) POLYMERS FOR IN VIVO NUCLEIC ACID DELIVERY
摘要
The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
申请公布号
CA2842041(A1)
申请公布日期
2013.10.24
申请号
CA20122842041
申请日期
2012.08.23
申请人
ARROWHEAD RESEARCH CORPORATION
发明人
WAKEFIELD, DARREN H.;ROSSI, NICHOLAS;ROZEMA, DAVID B.;ALMEIDA, LAUREN;PERILLO-NICHOLAS, ANTHONY L.