| 摘要 |
<p>Provided is a process for production of [ 18 F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for production of a radioactive fluorine-labeled organic compound, which comprises:
a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1):
wherein R 1 is a linear or branched C 1 -C 10 alkyl chain or an aromatic substituent; and R 2 is a protecting group; charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2):
wherein X is sodium or potassium; and
a deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):</p> |
