TRIS(HYDROXYMETHYL)AMINOMETHANE SALTS OF A SMALL-MOLECULE GLP1R AGONIST AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

摘要

The disclosure provides tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1 R agonist. The disclosure further provides solid compositions comprising tris(hydroxymethyl)aminomethane salts of the small-molecule GLP1R agonist. The disclosure further provides uses of tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist, e.g., for treating type 1 diabetes, type 2 diabetes, or obesity. Solid formulations further comprising an evaporation residue and a binder, such as hydroxy propyl methyl cellulose acetate succinate (HPMCAS), are also provided.