发明名称 |
DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS |
摘要 |
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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申请公布号 |
US2013245041(A1) |
申请公布日期 |
2013.09.19 |
申请号 |
US201213685128 |
申请日期 |
2012.11.26 |
申请人 |
BLAIR BROOKE;FATHEREE PAUL R.;FLEURY MELISSA;GENDRON ROLAND;HUDSON RYAN;MCKINNELL ROBERT MURRAY;WILSON MICHAEL |
发明人 |
BLAIR BROOKE;FATHEREE PAUL R.;FLEURY MELISSA;GENDRON ROLAND;HUDSON RYAN;MCKINNELL ROBERT MURRAY;WILSON MICHAEL |
分类号 |
C07D403/10;C07D231/12;C07D401/06;C07D401/14;C07D403/06 |
主分类号 |
C07D403/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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