NOVEL FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS

摘要

THE INVENTION RELATES TO NOVEL FLUORESCENT DERIVATIVES OF POLYAMINES HAVING A BENZOXADIAZOLE GROUP, TO A METHOD FOR PREPARING THE SAME AND TO THE USE THEREOF AS DIAGNOSIS TOOLS FOR EMPHASIZING THE POLYAMINE TRANSPORT SYSTEM IN CANCEROUS CELLS IN ORDER TO ADAPT THE TREATMENT THEREOF, AND THUS FOR SELECTING PATIENTS CARRYING SUCH TUMOURS IN ORDER TO ADAPT THEIR TREATMENT. THE DERIVATIVES ARE OF THE FORMULA (I) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, IN WHICH: R? IS ONE OR MORE NO? GROUPS IN POSITION 4 OR 6, OR A SO?PH, SO?NME?, SO?NH? OR SO?H GROUP; R? IS HYDROGEN, C?-? ALKYL, BENZYL, A PERFLUOROALKYL GROUP; THE VALUES OF A, B, C RANGE FROM 2 TO 5 INDEPENDENTLY FROM EACH OTHER AND REPRESENT ALKYLENE I CHAINS SEPARATING THE AMINO GROUPS, AND THE VALUES OF D AND E CAN INDEPENDENTLY BE 0 OR 1.