PHARMACEUTICAL COMPOSITION COMPRISING BEE VENOM-PHOSPHOLIPASE A2 (BV-PLA2) FOR TREATING OR PREVENTING DISEASES RELATED TO DEGRADATION OF ABNORMAL REGULATORY T CELL ACTIVITY

摘要

The present invention relates to a pharmaceutical composition comprising, as an active ingredient, a polypeptide which contains a bee venom-phospholipase A2 (BV-PLA2) amino acid sequence without a leader sequence for treating or preventing diseases related to a degradation of abnormal regulatory T cell activity. A secretory bee venom-phospholipase A2 (secretory BV-PLA2) of the present invention may activate a regulatory T cell and inhibit differentiation of Th1/Th17. Thus, the polypeptide of the present invention can be effectively used as a pharmaceutical composition for preventing or treating diseases related to a degradation of abnormal regulatory T cell activity, that is, autoimmune, allergic or neurodegenerative diseases.