METHOD FOR PROGNOSTIC DIAGNOSTICS OF UNFERTILITY OF VARIOUS ETIOLOGY IN MEN FROM REGIONS CONTAMINATED WITH RADIONUCLIDES

摘要

The invention relates to medicine, in particular to sexual pathology, and can be used for predictive diagnosis of infertility of various etiologies in men from contaminated regions. A method comprises the determination of features of Ubiquitin protein expression in the structural elements of the testis biopsy by immunohistochemistry coefficient, which is obtained by multiplying the values of the prevalence and intensity of color that are assessed semiquantitatively in points. In accordance with the invention, based on the results of morphological studies and the presence of certain performance ratios of immunohistochemical expression of Ubiquitin separately in the cytoplasm and nuclei of Sertoli cells and Leydig cells the excretory-obstructive, secretory or unified form of male infertility are determined, as well as treatment method for infertility and further predictions on fertility restoration.