发明名称 |
A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF |
摘要 |
A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described. |
申请公布号 |
EP2408739(B1) |
申请公布日期 |
2013.08.14 |
申请号 |
EP20100712320 |
申请日期 |
2010.03.11 |
申请人 |
EOS ETHICAL ONCOLOGY SCIENCE S.P.A. IN ABBREVIATED FORM EOS S.P.A. |
发明人 |
SPINELLI, SILVANO;LIVI, VALERIA |
分类号 |
C07C271/24;C07D215/22 |
主分类号 |
C07C271/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|