发明名称 |
Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan |
摘要 |
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
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申请公布号 |
US8507449(B2) |
申请公布日期 |
2013.08.13 |
申请号 |
US201213400303 |
申请日期 |
2012.02.20 |
申请人 |
TAM TIM FAT;N'ZEMBA BLAISE;LEUNG-TOUNG REGIS;WANG YINGSHENG;ZHAO YANQING;YU LILY;APOTEX TECHNOLOGIES INC. |
发明人 |
TAM TIM FAT;N'ZEMBA BLAISE;LEUNG-TOUNG REGIS;WANG YINGSHENG;ZHAO YANQING;YU LILY |
分类号 |
C07K5/072;A61K38/05 |
主分类号 |
C07K5/072 |
代理机构 |
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代理人 |
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地址 |
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