| 发明名称 |
2' AND 5' MODIFIED MONOMERS AND OLIGONUCLEOTIDES |
| 摘要 |
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
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| 申请公布号 |
US2013203836(A1) |
申请公布日期 |
2013.08.08 |
| 申请号 |
US201113638891 |
申请日期 |
2011.03.31 |
| 申请人 |
RAJEEV KALLANTHOTTATHIL G.;MANOHARAN MUTHIAH;SWAYZE ERIC E.;PRAKASH THAZHA P.;ISIS PHARMACEUTICALS, INC.;ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
RAJEEV KALLANTHOTTATHIL G.;MANOHARAN MUTHIAH;SWAYZE ERIC E.;PRAKASH THAZHA P. |
| 分类号 |
C12N15/113;A61K48/00;C07H19/06;C07H19/16 |
主分类号 |
C12N15/113 |
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