发明名称 PEPTIDE EPOXYKETONES FOR PROTEASOME INHIBITION
摘要 One aspect of the invention relates to inhibitors of formula (I) that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.
申请公布号 PT2041158(E) 申请公布日期 2013.07.17
申请号 PT20070809745T 申请日期 2007.06.19
申请人 ONYX THERAPEUTICS, INC. 发明人 GUY J. LAIDIG;MARK S. SMYTH;CATHERINE SYLVAIN;HAN-JIE ZHOU;KEVIN D. SHENK;FRANCESCO PARLATI;MARK K. BENNETT
分类号 A61K31/336;A61K31/404;A61K38/05;A61P35/00;A61P37/00;C07D303/32;C07D405/12;C07D409/12 主分类号 A61K31/336
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