COMPOSITION INCLUDING REBAMIPIDE AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING OBESITY

摘要

The present invention relates to a novel use of rebamipide which can prevent or treat obesity, and more particularly to a pharmaceutical composition and a health functional food for preventing or treating obesity, which includes a rebamipide compound or pharmaceutically acceptable salts thereof. Injection of a rebamipide compound to an obesity-induced mouse model shows remarkable loss in weight, number of adipose cells, and total body cholesterol content, compared to a non-injected control model. Also, the rebamipide compound is proven to provide the advantageous effects in that it remarkably represses cytotoxic Th17-cells which produce and secrete inflammatory cytokines, and increases the activity of regulatory T-cell (Treg) which inhibits abnormally activated immune cells and regulates inflammatory reaction. Thus, the rebamipide compound has the effect in which it can be used in the production of a treating agent or functional food which can effectively treat fatness and obesity caused by abnormal immune regulation.