发明名称 |
2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS |
摘要 |
The present invention relates to compounds of formula I wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
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申请公布号 |
US2013172335(A1) |
申请公布日期 |
2013.07.04 |
申请号 |
US201313773693 |
申请日期 |
2013.02.22 |
申请人 |
HOFFMANN-LA ROCHE INC.;HOFFMANN-LA ROCHE INC. |
发明人 |
HUNZIKER DANIEL;LERNER CHRISTIAN;MUELLER WERNER;OBST SANDER ULRIKE;PFLIEGER PHILIPPE;WALDMEIER PIUS |
分类号 |
C07D413/10;C07C255/57;C07D235/26;C07D263/58;C07D265/36;C07D317/60;C07D401/10;C07D403/12;C07D413/12;C07D455/02;C07D498/04 |
主分类号 |
C07D413/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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