| 摘要 |
PURPOSE: A manufacturing method of nyasol is provided to manufacture nyasol which has strong resistance to a bovine uterine estrogen receptor, hypnotization activity, testosterone 5alpha-reductase, restraining activity, and hypnotization activation. CONSTITUTION: A manufacturing method of nyasol comprises a step of obtaining compound A represented by chemical formula 1; a step of obtaining compound 11 by a reaction of compound B in the compound A solution; a step of obtaining compound 20 from the compound 11; a step of obtaining the compound 21 by reaction of the compound 20 solution; a step of obtaining compound 22 from the compound 21 solution; a step of obtaining compound 23 from alcohol 22 solution; a step of obtaining compound 25 from the compound 23; and a step of removing MOM substituent from the compound 25, extracting a reaction mixture by an organic solvent; and purifying the extract.
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