3-(3,4-DIMETHOXYPHENYL)-4,5,6,7-TETRAHYDROINDAZOLE HYDROCHLORIDE, ANALGESIC AND ANTIMICROBIAL AGENT

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to organic chemistry, namely a new biologically active compound of indazole: 3-(3,4-dimethoxyphenyl)-4,5,6,7-tetahydroindazole hydrochloride(I) having formula presented above. The declared compound exhibit analgesic activity, twice less than Analgin and having higher action level. Furthermore, it exhibits high bacteriostatic activity on Staphylococcus aureus (3.8 mg/ml) and manifested bacteriostatic activity on Staphylococcus epidermidis (15.6-31.2 g/ml), Staphylococcus saprophyticus (250 mcg/ml) and the fungus Candida albicans (500-1000 mcg/ml) as well as bactericidal activity on these three species of staphylococci (62.5, 500 and 1000 mcg/ml respectively), having higher action level than phenyl salicylate. The compound (I) is referred to low-toxic (LD=1500 mg/kg).EFFECT: invention refers to analgesic and antimicrobial agents representing the compound (I).3 cl, 2 tbl, 2 ex