Composition useful e.g. in topical treatment of inflammatory diseases of skin and/or mucous membrane, comprises fusafungine and its derivate, and acidic glycosaminoglycan or its derivatives

摘要

Composition comprises: (a) fusafungine and/or at least one fusafungine derivate; and/or (b) at least one acidic glycosaminoglycan or its salts or derivatives, preferably hyaluronic acid or its salts in effective amounts as active ingredients. An independent claim is also included for use of the composition for the topical treatment of inflammatory diseases of oral and pharyngeal cavity, and for preparation of a medicament for the prophylactic and/or therapeutic, preferably topical treatment of inflammatory diseases of the oral and pharyngeal cavity. ACTIVITY : Antiinflammatory; Dermatological; Antibacterial; Antiulcer. The antiinflammatory activity of the composition was tested in patients (19-71 years old) with aphthous ulcers in the mouth or throat by administering composition in the form of lozenge tablet containing fusafungine, hyaluronic acid, dexpanthenol and/or ectoine for 10 days. The result showed that the lozenge tablet exhibited reduction of aphthous ulcers (1.7) (according to the school grading system), compared to the tablets (in the form of mono preparation of fusafungine, hyaluronic acid, dexpanthenol or ectoine) (3.8). MECHANISM OF ACTION : None given.