RECOMBINANT MICROORGANISM WHICH SECRETES EGF VIA AN ABC TRANSPORTER, AND COMPOSITION FOR ALLEVIATING OR TREATING PEPTIC ULCERS COMPRISING SAME AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a recombinant microorganism which secretes EGF via an ABC transporter, and to a composition for alleviating or treating peptic ulcers comprising same as an active ingredient, and more specifically relates to a recombinant microorganism that has been genetically altered by means of a recombinant vector comprising a gene coding for epidermal growth factor and a recombinant vector comprising a gene coding for an ATP-binding cassette transporter, and relates to a composition for alleviating or treating peptic ulcers comprising the microorganism as an active ingredient. The microorganism according to the present invention is resistant to bodily digestive enzymes and so can survive in quantity as far as the intended target site, and it has a high epidermal-growth-factor protein expression efficiency and extracellular discharging effect and hence can exhibit an outstanding effect in treating peptic ulcers even in small doses.